Week 6 odds: Buccaneers favored over 49ers in matchup of 4-1 teams

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Sunday, October 12, 2025
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Week 6got underway with a matchup of NFC East rivals as thePhiladelphia Eagleswere upset 34-17 by theNew York Giants on "Thursday Night Football." The Eagles, who had won both matchups last season, were 7.5-point favorites.

Sunday features an intriguing matchup of 4-1 teams, with the Tampa Bay Buccaneers (-2.5) hosting the San Francisco 49ers, and concludes with the Kansas City Chiefs (-1.5) taking on the Detroit Lions.

The week finishes with a Monday night doubleheader, leading off with the Buffalo Bills(-3.5)facing the Atlanta Falcons and wrapping up with the Chicago Bears visiting the Washington Commanders(-4.5).

It's a bye week for a pair of teams, as the Minnesota Vikings, fresh off two international games, and the Houston Texans are resting.

Here's a look at the odds for every remaining Week 6 game.

>Sunday, 9:30 a.m., NFL Net, NFL+

Money Line: Broncos (-400); Jets (+300)

>Total: 43.5; Opened: 43.5

>FPI favorite: Broncos by 8.4 with a 71.07% probability to win the game outright

>Sunday, 1 p.m., CBS

Line movement: Opened Chargers -5.5

>Money Line: Chargers (-210); Dolphins (+175)

>Total: 43.5; Opened: 45.5

>FPI favorite: Chargers by 4 with a 61.07% probability to win the game outright

>Sunday, 1 p.m., FOX

Line movement: Opened Colts -5.5

>Money Line: Cardinals (+380); Colts (-550)

>Total: 46.5; Opened: 46.5

>FPI favorite: Colts by 9.3 with a 73.2% probability to win the game outright

>Sunday, 1 p.m., FOX

Money Line: Cowboys (-170); Panthers (+145)

>Total: 48.5; Opened: 48.5

>FPI favorite: Cowboys by 4.1 with a 61.73% probability to win the game outright

>Sunday, 1 p.m., FOX

Line movement: Opened Jaguars -1.5

>Money Line: Seahawks (-120); Jaguars (+100)

>Total: 47.5; Opened: 44.5

>FPI favorite: Jaguars by 0.1 with a 50% probability to win the game outright

>Sunday, 1 p.m., CBS

Money Line: Patriots (-200); Saints (+170)

>Total: 45.5; Opened: 46.5

>FPI favorite: Patriots by 4.1 with a 59.87% probability to win the game outright

>Sunday, 1 p.m., FOX

Money Line: Rams (-400); Ravens (+300)

>Total: 44.5; Opened: 44.5

>FPI favorite: Rams by 4.6 with a 62.33% probability to win the game outright

>Sunday, 1 p.m., CBS

Line movement: Opened Steelers -4.5

>Money Line: Browns (+240); Steelers (-290)

>Total: 38.5; Opened: 38.5

>FPI favorite: Steelers by 5.4 with a 63.33% probability to win the game outright

>Sunday, 4:05 p.m., FOX

Money Line: Titans (+190); Raiders (-225)

>Total: 41.5; Opened: 41.5

>FPI favorite: Raiders by 5.7 with a 64.53% probability to win the game outright

>Sunday, 4:25 p.m., CBS

Money Line: 49ers (+155); Buccaneers (-185)

>Total: 46.5; Opened: 46.5

>FPI favorite: Buccaneers by 5.7 with a 65% probability to win the game outright

>Sunday, 4:25 p.m., CBS

Money Line: Bengals (+800); Packers (-1600)

>Total: 44.5; Opened: 43.5

>FPI favorite: Packers by 13.2 with a 80.47% probability to win the game outright

>Sunday, 8:20 p.m., NBC

Money Line: Lions (+125); Chiefs (-145)

>Total: 51.5; Opened: 48.5

>FPI favorite: Chiefs by 2 with a 55.67% probability to win the game outright

>Monday, 7:15 p.m., ESPN

Money Line: Bills (-210); Falcons (+175)

>Total: 49.5; Opened: 49.5

>FPI favorite: Bills by 4.2 with a 60.93% probability to win the game outright

>Monday, 8:15 p.m., ABC

Money Line: Bears (+195); Commanders (-230)

>Total: 49.5; Opened: 49.5

>FPI favorite: Commanders by 6.2 with a 65.8% probability to win the game outright

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