NFL Week 4 betting: Odds, lines and totals for every game

Monday, September 28, 2026 3:25PM

One game remains in Week 3, but odds for Week 4 of the NFL season are out.

The Cleveland Browns host the Pittsburgh Steelers on Thursday night to open the action. The Steelers are a 2.5-point favorite in a game with the lowest total of the week (38.5).

The week is full of tight spreads, with 11 games having spreads of four points or less. The Baltimore Ravens (-11.5) hosting the Tennessee Titans and the Miami Dolphins visiting the Minnesota Vikings (-10) are the major outliers on the board.

The Jacksonville Jaguars-Cincinnati Bengals matchup has the highest points total of the week at 51.5. The Detroit Lions-Carolina Panthers tilt on Sunday night is right behind at 50.5.

Week 4 wraps up with an NFC South battle between the New Orleans Saints (-2.5) and Atlanta Falcons on "Monday Night Football" (8:15 p.m. on ESPN).

Here's a look at the odds for every game this week. (You can find our early bets for Week 4 here.)

Money Line: Steelers (-148); Browns (+124)

Total: 38.5; Opened: 40.5

FPI favorite: Steelers by 1.6 with a 56% probability to win the game outright

Line movement: Opened Commanders -1.5

Money Line: Colts (-166); Commanders (+140)

Total: 47.5; Opened: 48.5

FPI favorite: Colts by 1 with a 54% probability to win the game outright

Line movement: Opened Bears -8.5

Money Line: Jets (+130); Bears (-155)

Total: 42.5; Opened: 45.5

FPI favorite: Bears by 4.5 with a 66% probability to win the game outright

Line movement: Opened Bills -3

Money Line: Patriots (+250); Bills (-310)

Total: 48.5; Opened: 49.5

FPI favorite: Bills by 5.7 with a 71% probability to win the game outright

Line movement: Opened Packers -1.5

Money Line: Packers (-185); Buccaneers (+154)

Total: 39.5; Opened: 47.5

FPI favorite: Buccaneers by 1 with a 54% probability to win the game outright

Money Line: Cardinals (-115); Giants (-105)

Total: 44.5; Opened: 45.5

FPI favorite: Cardinals by 1.2 with a 55% probability to win the game outright

Money Line: Cowboys (+114); Texans (-135)

Total: 47.5; Opened: 47.5

FPI favorite: Cowboys by 1.5 with a 56% probability to win the game outright

Money Line: Jaguars (+114); Bengals (-135)

Total: 51.5; Opened: 51.5

FPI favorite: Jaguars by 1.3 with a 55% probability to win the game outright

Money Line: Rams (-130); Eagles (+110)

Total: 46.5; Opened: 47.5

FPI favorite: Rams by 1.8 with a 57% probability to win the game outright

Line movement: Opened Ravens -8.5

Money Line: Titans (+500); Ravens (-700)

Total: 43.5; Opened: 47.5

FPI favorite: Ravens by 10.1 with a 83% probability to win the game outright

Line movement: Opened Vikings -7.5

Money Line: Dolphins (+455); Vikings (-625)

Total: 39.5; Opened: 43.5

FPI favorite: Vikings by 9.8 with a 82% probability to win the game outright

Money Line: Broncos (+136); 49ers (-162)

Total: 46.5; Opened: 46.5

FPI favorite: 49ers by 7.8 with a 78% probability to win the game outright

Money Line: Chiefs (-238); Raiders (+195)

Total: 47.5; Opened: 43.5

FPI favorite: Chiefs by 5.6 with a 70% probability to win the game outright

Line movement: Opened Seahawks -3

Money Line: Chargers (+250); Seahawks (-310)

Total: 43.5; Opened: 45.5

FPI favorite: Seahawks by 6.7 with a 74% probability to win the game outright

Money Line: Lions (-180); Panthers (+150)

Total: 50.5; Opened: 45.5

FPI favorite: Lions by 3.3 with a 62% probability to win the game outright

Money Line: Falcons (+130); Saints (-155)

Total: 48.5; Opened: 45.5

FPI favorite: Saints by 3.4 with a 63% probability to win the game outright

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